Effectiveness of golden sea cucumber (Stichopus hermanii) extract gel on increasing RANKL expression process modeling in post extraction tooth

Efektivitas gel ekstrak teripang emas (Stichopus hermanii) terhadap peningkatan ekspresi RANKL pada proses remodeling tulang pascapencabutan gigi

Abstract

Socket preservation is a procedure in the tooth socket by inserting graft material so as to reduce bone and soft tissue loss after tooth extraction. Gold sea cucumber (S.hermanii) extract has been widely studied because it contains many bioactive compo-nents that can accelerate the post-extraction ossification process. Gold sea cucumber extract was made into gel preparations with concentrations of 0.8%, 1.6%, and 3.2%. The experimental animals were randomly divided into 4 groups. Immunohistoche-mical observation to see the increase in RANK-L expression after gel administration on day 14 after tooth extraction of guinea pigs. The mean levels of osteoclasts and RANKL were highest in the control group and lowest in the 3.2% group. The results of the one-way Anova test showed that there were significant differences between the four treatment groups (p<0.05). It was con-cluded that the administration of golden sea cucumber gel extract had an effect on the bone socket formation process. The most effective concentration of 3.2% was used in the process of socket bone formation.