Marine sponges as potential inhibitors of oral squamous cell carcinoma

Spons laut sebagai penghambat potensial karsinoma sel skuamosa oral

Abstract

Compound extracts from marine sponges are able to prevent the growth of cancer cells proliferation of malignant cells through the process of inducing apoptosis by chromatin condensation or DNA fragmentation that resulting in cancer cell apoptosis. This situation ultimately triggers the cell death programs through increasing the apoptotic pathway. This article is aimed to deter-mine the benefits of compounds derived from marine sponges in inhibiting the development of oral squamous cell carcinoma (OSCC). Several bioactive compounds produced from marine sponges such as manoalide, stellettin B, methanol extract T. swinhoi, ilimaquinone, stigmamasterol increase oxidative stress, produce oxidative stress N-acetylcysteine, Mito-Tempo and ZVAD oral cancer cells, antiproliferative effects in oral cancer cells, oxidative stress regulates the increasing of subG1, inhibits caspase 3 and 3/7 activation, triggers higher ER stress, stronger cytotoxicity in KB/C152 cells compared to Jurkat/E6-1 cells, activation of mitogen-activated protein kinase which is as a role in the occurrence of apoptosis and DNA damage in oral cancer cells indicates that the sponges have the potential to inhibit OSCC. It is concluded that compounds derived from marine sponges can take a part in apoptosis, antiproliferation, cytotoxicity in oral cancer cells so they have the potential to inhibit OSCC.