Effects of roses extract (Rosa damascena Mill.) on healing of Staphylococcus aureus and Candida albicans induced-angular cheilitis on wistar male rats

Efek ekstrak bunga mawar terhadap penyembuhan angular cheilitis yang diinduksi Staphylococcus aureus dan Candida albicans pada tikus jantan wistar

Abstract

One type of plant used as herbal medicine is rose (Rose damascena Mill) which contains phenolic compounds and essential oils; has multi efficacy especially against Staphylococcus aureus and Candida albicans. One of the oral diseases caused by these microbes is angular chelitis which is a lesion and inflammation that is a combined infection between Staphylococci, β-hemolytic Streptococcus, and Candida that affects the tissues in the corners of the mouth. Laboratoryexperimental research with a posttest only control group design using 24 male Wistar rats which were divided into group-1 induced by S.aures and gi-ven roseflower extract (RFE), group-2 induced by S.aureus and given gentamicin, group-3 induced by C.albicans and given RFE, and group-4 induced by C.albicans andgiven miconazole. All mice were treated and observed the wound length and ery-thema of each group for 7 days then the data were processed using the SPSS. On the third day, the wound length of group-1 dan -2 were 0.00±0.0 mm, group-3 was 0.08±0.20 mm, and group-4 was 0.16±0.39 mm. Friedman test showedsignificant dif-ferences in wound length in each treatment group. It is concluded that RFE has an effect on the healing of angular cheilitis in Wistar male white rats induced by S.aureus and C.albicans and RFE is more effective on the group induced by S.aureus.