Antifungal effectiveness of soursop (Annonamuricata Linn) leaves extract againts Candida albicans on heat cured acrylic
Efektivitas antifungi ekstrak daun sirsak (Annonamuricata Linn) terhadap Candida albicans pada akrilik polimerisasi panas
Abstract
Objective: The use of removable dentures can cause chronic inflammation, namely denture stomatitis, caused by Candida al-bicans; with a prevalence of 15-70%. Soursop (Annonamuricata Linn) leaf extract contains alkaloids, tanin, flavonoids, and sa-ponins that act as antifungals. This study is intended to evaluate whether soursop leaf extract solution can effectively reduce the number of C.albicans colonies in heat polymerized acrylic resins. Method: With true experimental pre-post test with control group design, 25 resin plates were divided into 5 groups, 3 groups were tested with soursop leaf extract (10%, 15% and 25%), while Fittydent® and aquadest were the control groups. Samples are contaminated with C.albicans suspension and incubated; calculated before immersion 8 hours, then put in Saboroud's brouth and recalculated. Result: Wilcoxon test showed significant differences in all groups, except the aquadest group. The Mann-Whitney test compared a decrease in the number of C.albicans colonies between groups, showed significant differences between treatment groups, except between the extract group of 25% and fittydent control®. Conclusion: Soursop leaf extract solution lowers the number of C.albicans colonies in heat polymeri-zation acrylic with the most effective concentration of 25%.
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